We report the case of focal nodular hyperplasia-like nodular hepatic lesion
s, that developed in the liver of a 35-year-old Caucasian female who requir
ed orthotopic liver transplantation for Budd-Chiari syndrome. The rapid dev
elopment of focal nodular hyperplasia-like lesions in a severe hepatic vasc
ular disorder and in the absence of cirrhosis may represent an additional a
rgument in favor of the vascular origin of focal nodular hyperplasia. The p
athogenesis of the nodules is not clear, but pathological arterialization o
f the liver in hepatic vein thrombosis may be a candidate mechanism.