Chimpanzees are susceptible to infection with human immunodeficiency virus
(HIV)-1; however, infected animals usually maintain normal numbers of CD4() T lymphocytes and do not develop immunodeficiency. We have examined 10 ch
ronically infected HIV-1-positive chimpanzees for evidence of progressive i
nfection. In addition to 1 animal that developed AIDS, 3 chimpanzees exhibi
t evidence of progressive HIV infection. All progressors have low CD4(+) T
cell counts (<200 cells/mu L), severe CD4:CD8 inversion, and marked reducti
on in interleukin-2 receptor expression by CD4(+) T cells. In comparison wi
th HIV-positive nonprogressor chimpanzees, progressors have higher plasma a
nd lymphoid virus loads, greater CD38 expression in CD8(+)/HLA-DR+ T cells,
and greater serum concentrations of soluble tumor necrosis factor type II
receptors and beta 2-microglobulin, all markers of HIV progression in human
s. These observations show that progressive HIV-1 infection can occur in ch
impanzees and suggest that the pathogenesis of progressive infection in thi
s species resembles that in humans.