Tremendous advances have been made in our understanding of the intrapersona
l, interpersonal, familial, and contextual characteristics and processes th
at contribute to adaptive as well as maladaptive developmental outcomes wit
h high-risk and clinically referred adolescents. This empirical knowledge b
ase offers clinically rich opportunities for systematic treatment developme
nt. An important step in this process is distinguishing which research find
ings in basic science areas such as developmental psychology and developmen
tal psychopathology might have clinical relevance Toward this goal, we revi
ew relevant but selective research in areas that are central to clinical wo
rk with adolescents (parent-adolescent relationship, biological aspects, an
d affect and cognition), and we offer examples of how basic research in the
se areas can inform treatment.