Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis

Authors
Fort, DM Ubillas, RP Mendez, CD Jolad, SD Inman, WD Carney, JR Chen, JL Ianiro, TT Hasbun, C Bruening, RC Luo, J Reed, MJ Iwu, M Carlson, TJ King, SR Bierer, DE Cooper, R
Citation
Dm. Fort et al., Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis, J ORG CHEM, 65(20), 2000, pp. 6534-6539
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
65
Issue
20
Year of publication
2000
Pages
6534 - 6539
Database
ISI
SICI code
0022-3263(20001006)65:20<6534:NATFPA>2.0.ZU;2-I
Abstract
Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethano lic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity.