SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY ELECTROPHORESIS .4. HYDROXYPROPYL-GAMMA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT

Authors
KOPPENHOEFER B EPPERLEIN U ZHU XF LIN BC
Citation
B. Koppenhoefer et al., SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY ELECTROPHORESIS .4. HYDROXYPROPYL-GAMMA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT, Electrophoresis, 18(6), 1997, pp. 924-930
Citations number
22
Categorie Soggetti
Biochemical Research Methods
Journal title
Electrophoresis → ACNP
ISSN journal
01730835
Volume
18
Issue
6
Year of publication
1997
Pages
924 - 930
Database
ISI
SICI code
0173-0835(1997)18:6<924:SOEODB>2.0.ZU;2-V
Abstract
In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-gamma-cyclodextrin as chir al solvating agent (CSA). A total of 30 drugs out of 86 could be resol ved in this straightforward approach. The number of experiments perfor med under identical conditions allows a statistical treatment of the d ata. The enantioseparation of the analytes is correlated with their in teraction strength with the CSA. Hence, the concentration of the CSA i s a crucial parameter for optimization of the enantioseparation, as sh own by a subset of 23 examples.