Recent advances in gestational trophoblastic disease

Recent advances have increased our understanding of gestational trophoblast ic disease, and epidemiologic studies have demonstrated that there are impo rtant differences in risk factors for complete and partial mole. Complete m oles are now increasingly being diagnosed in the first trimester, affecting their clinical presentation and pathologic characteristics. While importan t advances have been made in chemotherapy, it is note recognized that etopo side is associated with a risk of second tumors. Several studies have advan ced understanding of the molecular biology of gestational trophoblastic dis ease, and this is important for the eventual development of new and innovat ive therapy.