Objective: This prospective longitudinal study investigated the simultaneou
s impact of early biological and psychosocial risk factors on behavioral ou
tcome at school age. Method: A cohort of 362 children born between 1986 and
1988 with different biological (perinatal insults) and psychosocial risk f
actors (family adversity) was followed from birth to school age. When their
children were aged 8 years, parents of 89.0% of the initial sample complet
ed the Child Behavior Checklist (CBCL). Results: More externalizing as well
as internalizing problems were found in children born into adverse family
backgrounds, whereas no differences at broad-band syndrome level were appar
ent between groups with varying obstetric complications. Children with fami
ly risk factors had higher scores on 5 of the 8 CBCL scales (including atte
ntion, delinquent, and aggressive problems), whereas children with perinata
l risk factors had more social and attention problems than children in the
nonrisk groups. With one exception, no interactions between risk factors em
erged, indicating that perinatal and family risk factors contributed indepe
ndently to outcome. The differences between risk groups applied irrespectiv
e of gender. Conclusions: The adverse impact of family adversity clearly ou
tweighed the influence of obstetric complications in determining behavioral
adjustment at school age.