Conformational memory in enantioselective radical reductions and a new radical clock reaction

The radical decarboxylation of acid 1 led to tetrahydropyran 3 with signifi cant optical activity. This transfer of chirality is an example of a confor mational memory effect and derives from the slow ring inversion of the atro pisomer 2 and its enantiomer 2'. A similar conformational memory effect was observed in the reductive decyanation and reductive lithiation of cyanohyd rin 4. We propose that the racemization of radicals with chiral conformatio ns such as 2 could be used as new radical clocks. The rate of racemization of 2 was evaluated and used to determine the rate of H atom transfer to 2 b y different H atom donors. The rate of racemization of 2 is 5.7 x 10(8) s(- 1) at 22 degrees C, which is about five times faster than ring opening of a cyclopropylmethyl radical.