Selective contrast-enhanced MR angiography

In this study the feasibility of intraarterial contrast administration was investigated. Its use for navigation and treatment evaluation during MR-gui ded intravascular interventions was explored in phantom and animal experime nts. An injection protocol was developed, which accounts for sequence param eters and vessel flow rate. Tracking a bolus of contrast agent was useful t o verify the catheter tip position and to assess flow conditions. Compared to intravenous contrast-enhanced magnetic resonance angiography (CE-MRA), s elective contrast administration permitted a strongly reduced dose. In two- dimensional (2D) acquisitions overlap of vessels was prevented. Injection a nd acquisition were easily and accurately synchronized in selective 3D CE-M RA, and a high contrast concentration could be maintained during the entire acquisition. Selective injection is useful in the course of an interventio n, to facilitate navigation, provide information on flow conditions, and to evaluate treatment progress repeatedly. (C) 2000 Wiley-Liss, Inc.