Temperature distribution for combined laser hyperthermia-photodynamic therapy in the esophagus

Citation
J. Eichler et al., Temperature distribution for combined laser hyperthermia-photodynamic therapy in the esophagus, MED ENG PHY, 22(4), 2000, pp. 307-312
Citations number
12
Categorie Soggetti
Multidisciplinary
Journal title
MEDICAL ENGINEERING & PHYSICS
ISSN journal
13504533 → ACNP
Volume
22
Issue
4
Year of publication
2000
Pages
307 - 312
Database
ISI
SICI code
1350-4533(200005)22:4<307:TDFCLH>2.0.ZU;2-D
Abstract
In recent years photodynamic laser therapy (PDT) has been tested in animal and clinical studies for treatment of esophageal cancer. In several animal experiments a synergistic effect was found by simultaneously applying PDT a nd hyperthermia (HT). In this paper an optical fibre system is described wh ich can be used in the esophagus for combined PDT with a 1 W dye laser and HT with a 15 W Nd:YAG laser. A phantom was built simulating the geometry of the esophagus using cow muscle. The spatial temperature field during HT wa s measured Versus irradiation time. The results were compared with calculat ions using a coupled Monte Carlo laser transport/finite difference heat tra nsport model using the LATIS computer program. Measurements and calculation s yield a realistic description of the temperature distribution during HT u nder various experimental conditions. The LATIS program allows the predicti on of the effects of blood perfusion for in vivo situations. The results sh ow that perfusion has considerable influence on the temperature field, redu cing the effective depth in tissue for HT. (C) 2000 IPEM. Published by Else vier Science Ltd, All rights reserved.