In vitro susceptibilities of 11 clinical isolates of Exophiala species to six antifungal drugs

Authors
Meletiadis, J Meis, JFGM de Hoog, GS Verweij, PE
Citation
J. Meletiadis et al., In vitro susceptibilities of 11 clinical isolates of Exophiala species to six antifungal drugs, MYCOSES, 43(7-8), 2000, pp. 309-312
Citations number
20
Categorie Soggetti
Microbiology
Journal title
MYCOSES
ISSN journal
09337407 → ACNP
Volume
43
Issue
7-8
Year of publication
2000
Pages
309 - 312
Database
ISI
SICI code
0933-7407(2000)43:7-8<309:IVSO1C>2.0.ZU;2-1
Abstract
The antifungal activities of miconazole, terbinafine, itraconazole, UR 9825 , voriconazole and amphotericin B against 11 clinical isolates of Exophiala spp. were tested by the broth microdilution method. All drugs were very ac tive against Exophiala spp.. The 90% minimal inhibitory concentration (MIC9 0) ranged from 0.125 to 1 mu g ml(-1). Terbinafine was the most active drug against Exophiala spinifera, Exophiala dermatitidis and Exophiala castella nii and seems to be a promising agent in the treatment of infections caused by these fungi.