A debut for mito-mouse

Authors
Shoubridge, EA
Citation
Ea. Shoubridge, A debut for mito-mouse, NAT GENET, 26(2), 2000, pp. 132-134
Citations number
12
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
26
Issue
2
Year of publication
2000
Pages
132 - 134
Database
ISI
SICI code
1061-4036(200010)26:2<132:ADFM>2.0.ZU;2-H
Abstract
The inability to construct animal models of human diseases caused by mutate d mitochondrial DNA (mtDNA) has been a major obstacle to investigating path ogenetic mechanisms associated with specific mtDNA mutations. Mice carrying a large-scale deletion in mtDNA have now been produced. They display some of the key features of the human disorder, but there are surprising differe nces.