Corpus callosum size in autism

The size of the seven subregions of the corpus callosum was measured on MRI scans from 22 non-mentally retarded autistic subjects and 22 individually matched controls. Areas of the anterior subregions were smaller in the auti stic group. In a subsample, measurements were adjusted for intracranial, to tal brain, and white matter volumes and the differences between groups rema ined significant. No differences were found in the other subregions. This o bservation is consistent with the frontal lobe dysfunction reported in auti sm.