Eyelid abnormalities in lamellar ichthyoses

Purposes To describe eyelid abnormalities in lamellar ichthyoses (LI). Designs Retrospective observational case series. Participants: Eight patients with classic LI and two patients with congenit al ichthyosiform erythroderma. Methods: Results of eyelid and corneal examinations of 10 patients with LI were reviewed and analyzed with emphasis on the relationship between eyelid ectropion and corneal damage. Results: All patients presented with cicatricial lagophthalmos, Of the eigh t patients with classic LI, five had ectropion of the four eyelids, one had only lower ectropion, and two had no degree of ectropion. Two patients wit h congenital ichthyosiform erythroderma had distinct eyelid abnormalities, including madarosis and eyelash retraction. Loss of vision caused by cornea l damage was found in three patients with classic LI. Of these three patien ts, two did not have upper eyelid ectropion. Conclusions: Severe corneal damage can occur in LI even if there is no uppe r or lower eyelid ectropion, Ophthalmology 2000; 107:1895-1898 (C) 2000 by the American Academy of Ophthalmology.