Highly enantioselective addition of diethylzinc to diphenylphosphinoyl imines under dual amino alcohol/halosilane mediation

Authors
Jimeno, C Reddy, KS Sola, L Moyano, A Pericas, MA Riera, A
Citation
C. Jimeno et al., Highly enantioselective addition of diethylzinc to diphenylphosphinoyl imines under dual amino alcohol/halosilane mediation, ORG LETT, 2(20), 2000, pp. 3157-3159
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
20
Year of publication
2000
Pages
3157 - 3159
Database
ISI
SICI code
1523-7060(20001005)2:20<3157:HEAODT>2.0.ZU;2-3
Abstract
[GRAPHICS] Arylethylene derived, enantiomerically pure amino alcohols have been evalua ted as ligands for the dual-catalyzed (amino alcohol/halosilane) enantiosel ective addition of diethylzinc to diphenylphosphinoyl imines. Among them, t he conformationally restricted g-fluorenone derived ligand 4c provides the highest enantioselectivities so far reported over a range of substrate imin es.