SPECTRAL STUDIES AND IN-VITRO ANTIMICROBIAL ACTIVITY OF NEW ORGANOTIN(IV) COMPLEXES OF SCHIFF-BASES DERIVED FROM AMINO-ACIDS

Some new di- and triphenyltin(IV) complexes of the general formulae Ph 2SnL and Ph3SnL', where H2L/HL' = Schiff bases derived from the conden sation of 2-hydroxy-1-naphthaldehyde (H2L) and benzaldehyde (HL') with glycine (H2L-1/HL'-1), DL-alpha-alanine (H2L-2/HL'-2), L-methionine ( H2L-3/HL'-3), DL-valine (H2L-4/HL'-4), D-phenylalanine (H2L-5/HL'-5), 2-aminobutyric acid (H2L-6/HL'-6), and L-leucine (H2L-7/HL'-7), have b een synthesized and characterized by elemental analyses, molar conduct ance, electronic, infrared and far-infrared, multinuclear magnetic res onance (H-1, C-13, and Sn-117), and Sn-119 Mossbauer studies. Thermal decomposition of a few complexes using TG, DTG, and DTA techniques ind icates the formation of SnO2 as a residue. The complexes have also bee n tested in vitro against bacteria [Streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus Penicillin resistance (2500 units)] and fungi [Candida albicans , Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mentag rophytes, and Aspergillus fumigatus]. All of the complexes show remark able activity.