Galanin and its analogues modified in position 14: Chemical synthesis and biological activity

Authors
Ruczynski, J Szyk, A Konstanski, Z Korolkiewicz, R Rekowski, P
Citation
J. Ruczynski et al., Galanin and its analogues modified in position 14: Chemical synthesis and biological activity, POL J CHEM, 74(10), 2000, pp. 1375-1384
Citations number
45
Categorie Soggetti
Chemistry
Journal title
POLISH JOURNAL OF CHEMISTRY
ISSN journal
01375083 → ACNP
Volume
74
Issue
10
Year of publication
2000
Pages
1375 - 1384
Database
ISI
SICI code
0137-5083(200010)74:10<1375:GAIAMI>2.0.ZU;2-M
Abstract
In search of a specific galanin receptor antagonist, 15-amino-acid-residue analogues of porcine galanin modified in position 14 were synthesized and t heir activity was studied on isolated rat smooth muscles. It was shown that all galanin analogues contracted rat gastric fundus strips in a concentrat ion-dependent manner with significantly increased activities as compared to GAL(I-IS)NH2. The results suggest that position 14 in the amino acid seque nce of GAL(1-15)NH2 is important for the biological activity.