Clozapine treatment of outpatients with schizophrenia: Outcome and long-term response patterns

Objective: The purpose of the study was to examine the effects of clozapine in treating moderately ill schizophrenic outpatients and to determine the length of medication trial needed to identify responders and nonresponders. Methods: Rates of clinical response, relapses and hospitalizations, and le vels of symptomatology and functioning were assessed for 30 chronic schizop hrenic outpatients who received clozapine for one year, For some patients, data on relapse and hospitalization during treatment were compared with dat a from the year before treatment. Results: Eighteen of the 30 patients met criteria for sustained response; 17 of the responders were identified withi n the first four months of treatment, Patients experienced significantly fe wer relapses and hospitalizations during treatment than in the previous yea r. Improvement in positive symptoms, general symptomatology, and levels of functioning reached a plateau during the first six months of treatment and remained at that level during the second sir months, Negative symptoms and quality of life showed nonsignificant improvements at 12 months, Conclusion s: Results support the use of clozapine in treating chronic, residually sym ptomatic schizophrenic outpatients, A four-month clozapine trial may be ade quate to detect clinical responders in this population.