Sc. Licata et al., Repeated stimulation of L-type calcium channels in the rat ventral tegmental area mimics the initiation of behavioral sensitization to cocaine, PSYCHOPHAR, 152(1), 2000, pp. 110-118
Rationale: A substantial body of evidence indicates that ion flux through L
-type calcium channels and N-methyl-D-aspartate (NMDA) receptors contribute
s to behavioral sensitization to cocaine. Objectives: The following experim
ents were designed to evaluate the role of calcium influx through L-type ca
lcium channels or NMDA receptors in the ventral tegmental area (VTA) in the
initiation of behavioral sensitization to cocaine. Methods: The L-type cal
cium channel agonist BayK 8644, the glutamate agonist NMDA, or vehicle was
microinjected into the VTA on 3 consecutive days. Following a 2-week withdr
awal period, all rats received a challenge injection of cocaine (15 mg/kg,
i.p.) in order to assess potential cross-sensitization with the NMDA or Bay
K 8634 pretreatments. Results: Repeated intra-VTA microinjections of BayK 8
644, but not NMDA, resulted in an augmentation of the behavioral response t
o cocaine. Conclusions. These results indicate that calcium influx through
L-type calcium channels produces neurophysiological adaptations that mimic
those resulting from intermittent exposure to cocaine.