Absolute configuration and anti-hypercholesterolemic activity of (+)- and (-)-4-(2,6-dimethylheptyl)benzoic acids

Authors
Gamalevich, GD Vlasyuk, AL Voblikova, VA Serebryakov, EP
Citation
Gd. Gamalevich et al., Absolute configuration and anti-hypercholesterolemic activity of (+)- and (-)-4-(2,6-dimethylheptyl)benzoic acids, RUSS CHEM B, 49(7), 2000, pp. 1313-1315
Citations number
10
Categorie Soggetti
Chemistry
Journal title
RUSSIAN CHEMICAL BULLETIN
ISSN journal
10665285 → ACNP
Volume
49
Issue
7
Year of publication
2000
Pages
1313 - 1315
Database
ISI
SICI code
1066-5285(200007)49:7<1313:ACAAAO>2.0.ZU;2-G
Abstract
The biologically inactive (+)-enantiomer of 4-(2,6-dimethylheptyl)benzoic a cid was converted into the known (R)-3,7-dimethyloctanol with ee greater th an or equal to 96% by ozonolysis followed by a two-step reduction of the oz onide. This confirmed the R configuration of the starting acid, the S confi guration of its biologically active levorotatory antipode, and the absolute configurations assigned to their synthetic precursors.