ACQUIRED HYPOPHYSITIS IN ADOLESCENCE

Lymphocytic and granulomatous hypophysitis are rare causes of anterior pituitary dysfunction, diabetes insipidus and hyperprolactinemia, The clinical, radiographic, and laboratory features of hypophysitis in tw o adolescent girls are presented along with a review of the medical li terature. These subjects represent the youngest cases of autoimmune (l ymphocytic) and granulomatous hypophysitis reported to date. While hyp ophysitis remains an unusual cause of pituitary dysfunction, it may al so occur in early adolescence.