Periodic lateralized epileptiform discharges: association with seizures

Citation
B. Baykan et al., Periodic lateralized epileptiform discharges: association with seizures, SEIZURE-E J, 9(6), 2000, pp. 402-406
Citations number
23
Categorie Soggetti
Neurology
Journal title
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
ISSN journal
10591311 → ACNP
Volume
9
Issue
6
Year of publication
2000
Pages
402 - 406
Database
ISI
SICI code
1059-1311(200009)9:6<402:PLEDAW>2.0.ZU;2-2
Abstract
The clinical features and EEGs of 45 consecutive patients (40 adults and 5 children) who had periodic lateralized epileptiform discharges (PLEDs) were reviewed to determine the relationship between seizures and PLEDs. Focal e ncephalitis and ischemic stroke were the most frequent underlying processes for adult patients. All of the children, but only six of the adults, had l ong-lasting cerebral disorders whereas the remaining adults had acute or su bacute illness. There were 38 patients (84.4%) experiencing a seizure disor der. Twenty-six of them had their first seizure during their acute illness, as the pattern of PLED was encountered. Eight cases had status epilepticus , and seven of them had epilepsia partialis continue. Nineteen patients had a recent seizure in the day when PLEDs were observed hut not during EEG re cording; 12 patients had their seizures within 10 days before the observati on of PLED. PLEDs were grouped into three categories with respect to their extensions: lateralized to one hemisphere (n = 22), localized in one region (n = 17) and being prominent over one side with contralateral spread (n = 6). The last group was found to be more closely associated with frequent se izures or status epilepticus than the other two groups, our results showed that PLEDs were highly correlated with recent seizures in the majority of t he patients. These EEG findings may be considered as a manifestation of an increased neuronal excitability caused by different etiologies; but not an ictal pattern. (C) 2000 BEA Trading Ltd.