A RECURRENT TRANSLOCATION, T(16-21)(Q24-Q22), ASSOCIATED WITH ACUTE MYELOGENOUS LEUKEMIA - IDENTIFICATION BY FLUORESCENCE IN-SITU HYBRIDIZATION

Chromosome fluorescence in situ hybridization (FISH) analyses were per formed on bone marrow cells in 3 adult patients with MDS or AML, with a (16;21)(q24;q22) translocation, FISH analyses with AML1 probes at 21 q22 proved in all 3 patients splitting of the AML1 gene at a region sp anning exons 5 and 6 and the translocation of its 5' segment to distal 16q. Chromosome painting FISH analysis in patient 1 proved the transl ocation of the distal 21q segment to 16q, but it failed to prove the p resumed translocation of the distal 16q segment to 21q, most likely be cause of its small size. (C) Elsevier Science Inc., 1997.