BAND 1P36 ABNORMALITIES AND T(1-17) IN OVARIAN-CARCINOMA

In a series of 128 karyotyped ovarian carcinomas, 42% of cases with ch romosome 1 clonal structural abnormalities had breaks at band 1p36 (us ually involving translocations of unknown material). Fluorescent in si tu hybridization (FISH) studies using combinations of 1 centromere and 1p36.3-specific probes (16 cases) or I centromeric and 17 whole-chrom osome paint probes (11 cases with 1p+) revealed a trend toward deletio n of 1pter relative to 1 centromere (63%); intratumor heterogeneity; a nd the origin of 1p+ in 3/11 cases (27%) from chromosome 17 [t(1;17)(p 36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for ge nes important in the pathogenesis of a subset of sporadic ovarian carc inomas. (C) Elsevier Science Inc., 1997.