TRANSLOCATION (8-12-21)(Q22.1-Q24.1-Q22.1) - A NEW MASKED TYPE OF T(8-21)(Q22-Q22) IN A PATIENT WITH ACUTE MYELOID-LEUKEMIA

Authors
SAITOH K MIURA I OHSHIMA A TAKAHASHI N KUME M UTSUMI S KOBAYASHI Y HASHIMOTO K HATANO Y NIMURA T SAITO M ENOMOTO K OHHIRA M SHIMIZU K OHKI M MIURA AB
Citation
K. Saitoh et al., TRANSLOCATION (8-12-21)(Q22.1-Q24.1-Q22.1) - A NEW MASKED TYPE OF T(8-21)(Q22-Q22) IN A PATIENT WITH ACUTE MYELOID-LEUKEMIA, Cancer genetics and cytogenetics, 96(2), 1997, pp. 111-114
Citations number
16
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
96
Issue
2
Year of publication
1997
Pages
111 - 114
Database
ISI
SICI code
0165-4608(1997)96:2<111:T(-ANM>2.0.ZU;2-W
Abstract
The translocation t(8; 21)(q22; q22) is found in 40% of cases of acute myeloid leukemia (AML) designated as the subtype M2 in the French-Ame rican-British (FAB) classification. The 8; 21 translocation is clinica lly of interest because patients with this subtype have a good prognos is. We describe a masked type of the translocation, t(8; 12; 21)(q22.1 ; q24.1; q22.1). The translocation was first interpreted as t(8; 12)(q 22; q24) based on cytogenetics, but was reevaluated as a result of Sou thern blot and fluorescence in situ hybridization (FISH) analyses. (C) Elsevier Science Inc., 1997.