Jp. Park et al., DIFFUSE LARGE-CELL, B-CELL TYPE LYMPHOMA WITH A NOVEL TRANSLOCATION (2-22)(P23-Q11.2), Cancer genetics and cytogenetics, 96(2), 1997, pp. 118-122
We observed a translocation (2;22)(p23;q11.2) in the bone marrow cells
of a patient with multiple subcutaneous nodules. Tumor histology and
immunohistochemical staining demonstrated a malignant lymphoma, diffus
e large cell type, displaying a CD30 negative B cell immunophenotype.
To our knowledge, this is the first report of this specific translocat
ion in lymphoma, which may join the site of the anaplastic lymphoma ki
nase (ALK) gene at 2p23 to the region of the immunoglobulin lambda lig
ht chain gene at 22q11.2. The ALK gene was initially identified throug
h its involvement in the t(2;5)(p23;q35) found most commonly in anapla
stic large cell lymphoma. This observation in a CD30 negative large ce
ll lymphoma of B cell lineage further ex-tends the relationship of ana
plastic large cell morphology, ALK activation, lymphoid lineage, and e
xpression of the CD30 antigen. (C) Elsevier Science Inc., 1997.