One pot synthesis of 1-chloro-2-chlorocarboxy-4H-quinolizin-4-one and its derivatives

Authors
Han, Y Cai, LS Segal, BM
Citation
Y. Han et al., One pot synthesis of 1-chloro-2-chlorocarboxy-4H-quinolizin-4-one and its derivatives, SYN COMMUN, 30(21), 2000, pp. 3985-3995
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
30
Issue
21
Year of publication
2000
Pages
3985 - 3995
Database
ISI
SICI code
0039-7911(2000)30:21<3985:OPSO1A>2.0.ZU;2-2
Abstract
Condensation of 2-pyridine acetic acid with thionyl chloride under reflux c onditions generates the title compound in one step with >95% yield. Its rea ctivity toward alcohols and amines were investigated. All of the derivative s were characterized by NMR and MS analysis. One of its derivatives, 1-chlo ro-2-methoxycarboxy-4H-quinolizin-4-one, 5, was also characterized by X-ray diffraction studies.