A NOVEL CHROMOSOMAL ABNORMALITY INVOLVING CHROMOSOME-2 AND CHROMOSOME-18 IN A PATIENT WITH MYELODYSPLASTIC-SYNDROME

Authors
VINIOU N ABAZIS D YATAGANAS X BENKHALIFA M STAMATOPOULOS K VAYOPOULOS G PLATA E LOUKOPOULOS D PANGALOS C
Citation
N. Viniou et al., A NOVEL CHROMOSOMAL ABNORMALITY INVOLVING CHROMOSOME-2 AND CHROMOSOME-18 IN A PATIENT WITH MYELODYSPLASTIC-SYNDROME, Cancer genetics and cytogenetics, 96(1), 1997, pp. 7-12
Citations number
24
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
96
Issue
1
Year of publication
1997
Pages
7 - 12
Database
ISI
SICI code
0165-4608(1997)96:1<7:ANCAIC>2.0.ZU;2-0
Abstract
Cytogenetic analysis of bone marrow cells from a patient with myelodys plastic syndrome associated with eosinophilia showed a complex translo cation with a 46,XY,t(2;18;2)(p23;q11;q32) karyotype The patient has r efractory anemia (RA) according to the French-American-British Coopera tive Group (FAB) classification, and after 90 months of follow-up he s hows no evidence of leukemic transformation. This chromosomal abnormal ity has not been previously described in myelodysplastic syndromes and may be associated with good prognosis as the patient has been stable for a long time. (C) Elsevier Science Inc., 1997.