Characteristics and outcome of endometrial carcinoma patients age 45 yearsand younger

Recent reports have suggested that the pathologic Features of young patient s with endometrial cancer are less favorable than previously thought. We re trospectively reviewed the characteristics and outcome of young patients wi th endometrial cancer at our institution. A total of 457 surgically staged patients were divided in 2 groups: Group A (age less than or equal to 45 ye ars, n = 41) and B (age >45, n = 416). Groups A and B had a similar distrib ution of tumor stage, grade, histology, lymphovascular invasion, synchronou s ovarian primaries, and positive cytology, Although group A tumors had les s myometrial invasion (MI) (p = 0.004) and were lower grade (p = 0.06), a t rend to more frequent nodal involvement was seen in group A women (p = 0.09 ). Adverse pathologic features, in particular deep MI, were more common in group A patients older than age 40. Group A patients had a disease-free (p = 0.56) and cause-specific (p = 0.26) survival that was similar to that of group B patients. Young patients with endometrial cancer have a distributio n of most pathologic Features and equivalent outcome similar to that of old er women. However, adverse features are not equally distributed in young wo men. A discordance may also exist between MI, grade, and nodal involvement.