SYNTHESIS AND PHARMACOLOGICAL STUDY OF ETHYL D-4-OXO-3(4H)-QUINAZOLINYL]-1H-PYRAZOLE-4-ACETATES

A number of new ethyl -[4-oxo-3(4H)-quinazolinyl]-1H-pyrazole-4-acetat es substituted at the 2 position of the quinazolinone ring were prepar ed. The compounds were tested for analgesic and antiinflammatory activ ities, as well as for their acute toxicity and ulcerogenic effect. The 2-methyl, 2-ethyl and 2-phenyl derivatives proved to be more active t han acetylsalicylic acid and phenylbutazone in the phenylbenzoquinone writhing test. The 2-methyl derivative was also as active as acetylsal icylic acid in the carrageenin paw oedema test. All the compounds show ed very reduced ulcerogenic effects and systemic toxicity.