El. Segura et al., Long-term effects of a nationwide control program on the seropositivity for Trypanosoma cruzi infection in young men from Argentina, AM J TROP M, 62(3), 2000, pp. 353-362
Citations number
37
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Unselected nationwide cohorts of Argentine men 18 years of age summoned for
military service were tested for antibodies to Trypanosoma cruzi each year
from 1981 to 1993. After an initial screening using indirect hemagglutinat
ion test, the positive sera were retested by titrated indirect hemagglutina
tion and immunofluorescence antibody tests at 39 laboratories or at the nat
ional reference center in Buenos Aires. Nearly 1.8 million men were examine
d for T. cruzi antibodies using the same standardized procedures under a qu
ality assurance program. The prevalence of seropositivity for T. cruzi decr
eased significantly from 5.8% in 1981 to 1.9% in 1993, but the decrease was
not homogeneous among provinces within each region or constant over time.
Prior to the nationwide control campaign initiated in 1961-1962, 15 provinc
es had high (> 20%) percentages of houses with domiciliary infestation by T
riatoma infestans bugs, which decreased to nine provinces in 1982, and four
provinces in 1992. The observed decrease in the prevalence of seropositivi
ty far T. cruzi may be mostly attributed to the spraying with insecticides
to eliminate the domiciliary populations of Triatoma infestans. The lack of
a sustainable triatomine surveillance program set a limit to the decrease
of seropositivity rates and prompted a revised strategy based on community
participation.