Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin

Hemagglutinin (HA) is the receptor-binding and membrane fusion glycoprotein of influenza virus and the target for infectivity-neutralizing antibodies. The structures of three conformations of the ectodomain of the 1968 Hong K ong influenza virus HA have been determined by X-ray crystallography: the s ingle-chain precursor, HA0; the metastable neutral-pH conformation found on virus, and the fusion pH-induced conformation. These structures provide a framework for designing and interpreting the results of experiments on the activity of HA in receptor binding, the generation of emerging and reemergi ng epidemics, and membrane fusion during viral entry.