Comparison of biochemical blood traits after long-term selection on high or low locomotory activity in mice

In a long term experiment laboratory mice were selected for high (line DU-h TP) or low (line DU-lTP) paternal treadmill performance to differentiate th e endurance fitness. In generation 54 six enzymes and seven substrates were investigated in the blood plasma of males and females in DU-hTP (n = 104) and DU-lTP (n = 141). Compared with line DU-lTP in line DU-hTP significantl y higher enzyme activities, increased glucose concentration and lower level of triglycerides were found. The components of total cholesterol were dive rgent between the two lines and positively effected in DU-hTP for higher HD L-cholesterol. Animals with high endurance fitness showed a higher gain in the HDL-cholesterol concentration with increased total cholesterol level in the blood than gain of LDL+VLDL-cholesterol concentration.