Sm. Pransky et al., Clinical update on 10 children treated with intralesional cidofovir injections for severe recurrent respiratory papillomatosis, ARCH OTOLAR, 126(10), 2000, pp. 1239-1243
Objectives: To continue assessment of the benefits and risks of intralesion
al administration of cidofovir, an acyclic nucleoside phosphonate, for trea
ting severe recurrent respiratory papillomatosis (RRP) in pediatric patient
s,and to discuss guidelines for larger prospective multi-institutional stud
ies of the use of cidofovir.
Design: Prospective case series. getting: Tertiary care children's hospital
.
Patients: A total of 10 patients with severe RRP (defined as requiring debu
lking procedures to maintain airway patency at least once a month) underwen
t intralesional cidofovir therapy. The original 5 patients have received mo
re than 1 year of follow-up since their last cidofovir injection, and 5 sub
sequent patients have been treated with a revised injection protocol.
Intervention: Microsuspension laryngoscopy with intralesional injection of
cidofovir after repetitive carbon dioxide laser treatments and mechanical d
ebulking of papillomas.
Main Outcome Measures: Papilloma stage at the time of serial laryngoscopies
. Histologic examination of biopsy specimens of laryngeal tissue obtained 1
year or more after last cidofovir injection.
Results: There was evidence of marked improvement in the 4 of the 5 new pat
ients enrolled under the revised injection protocol, continuation of a dise
ase-free state in 1 of the original 5 patients, and sustained improvement i
n 4 of the 5 original patients, resulting in a significantly reduced interv
al of intervention.
Conclusions: Intralesional cidofovir therapy continues to show benefit in t
he treatment of severe RRP in pediatric patients. Safety profiles have not
been fully established, but current histologic data are reassuring.