Hypothetical 92.3-kD human protein homologous to angiotensin-converting enzyme: A new member of the zinc metalloprotease family?

Authors
Buchatskii, AG Kazachenko, KY Alexandrov, AA
Citation
Ag. Buchatskii et al., Hypothetical 92.3-kD human protein homologous to angiotensin-converting enzyme: A new member of the zinc metalloprotease family?, BIOCHEM-MOS, 65(9), 2000, pp. 1019-1022
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMISTRY-MOSCOW
ISSN journal
00062979 → ACNP
Volume
65
Issue
9
Year of publication
2000
Pages
1019 - 1022
Database
ISI
SICI code
0006-2979(200009)65:9<1019:H9HPHT>2.0.ZU;2-9
Abstract
Significant identity between a hypothetical 92.3-kD human protein and angio tensin-converting enzyme (ACE; peptidyl-dipeptidase A; kininase II) has bee n found. Certain specific regions of the 92.3-kD protein indicate that this unidentified molecule may be a member of the zinc metalloprotease family. A method is suggested for determination of a structural and functional fami ly of proteins with unknown structure and function.