W. Hilbe et al., Unusual adverse events following peripheral blood stem cell (PBSC) mobilisation using granulocyte colony stimulating factor (G-CSF) in healthy donors, BONE MAR TR, 26(7), 2000, pp. 811-813
Citations number
33
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Here, we describe two cases of severe pyogenic infection in healthy donors
diagnosed immediately following stem cell mobilisation with G-CSF, In the f
irst donor a painful perianal abscess and in the second one an apical absce
ss required surgical incision. The reported serious adverse events in the l
iterature are reviewed and the potential pathophysiological role of G-CSF o
r GM-CSF in augmenting inflammatory processes is discussed. In the light of
a rapidly increasing number of related and unrelated peripheral blood stem
cell donations the need for more comprehensive donor work-up and follow-up
for peripheral blood stem cell donors has to be considered.