Effective treatment of frontal hyperhidrosis with botulinum toxin A

Citation
I. Kinkelin et al., Effective treatment of frontal hyperhidrosis with botulinum toxin A, BR J DERM, 143(4), 2000, pp. 824-827
Citations number
16
Categorie Soggetti
Dermatology,"da verificare
Journal title
BRITISH JOURNAL OF DERMATOLOGY
ISSN journal
00070963 → ACNP
Volume
143
Issue
4
Year of publication
2000
Pages
824 - 827
Database
ISI
SICI code
0007-0963(200010)143:4<824:ETOFHW>2.0.ZU;2-L
Abstract
Background Focal hyperhidrosis is a common condition mostly confined to the axillae, palms and soles. In some individuals, predominantly men, increase d sweating of the forehead may be the major complaint and may interfere wit h the person's quality of life. Botulinum toxin A has been shown to be a ve ry effective treatment for focal hyperhidrosis of the axillae and palms. Objectives To assess the response in 10 men suffering from frontal hyperhid rosis treated with botulinum toxin A. Methods Botulinum toxin A Botox(R) was injected at multiple sites evenly di stributed over the forehead (mean dose 86 mouse units). Results The mean +/- SEM amount of sweat was significantly reduced, 4 weeks after treatment, from 173.8 +/- 38.6 mg min(-1) to 53.7 +/- 17.6 mg min(-1 ). The effect lasted at least 5 months in nine of the 10 patients. All pati ents subjectively judged the treatment as very effective. Minor side-effect s included painful injections and a transient weakness of forehead muscles without ptosis. Conclusions In this study, we provide evidence that botulinum toxin A is an effective and safe treatment for frontal hyperhidrosis.