Two-step immunoablative treatment with autologous peripheral blood CD34(+)cell transplantation in an 8-year-old boy with autoimmune haemolytic anaemia

Authors
Paillard, C Kanold, J Halle, P Yakouben, K Boiret, N Rapatel, C Berger, M Malpuech, G Demeocq, F
Citation
C. Paillard et al., Two-step immunoablative treatment with autologous peripheral blood CD34(+)cell transplantation in an 8-year-old boy with autoimmune haemolytic anaemia, BR J HAEM, 110(4), 2000, pp. 900-902
Citations number
6
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
110
Issue
4
Year of publication
2000
Pages
900 - 902
Database
ISI
SICI code
0007-1048(200009)110:4<900:TITWAP>2.0.ZU;2-2
Abstract
Life-threatening haemolysis in children with autoimmune haemolytic anaemia (AIHA) occurs rarely. Many cases of severe autoimmune disease are currently treated with immunosuppressive high-dose chemotherapy and autograft. We re port here a case of a child with severe AIHA who did not respond to convent ional treatments, but was cured with an autologous peripheral blood CD34(+) cell transplantation. After d 16 post autograft, no further red cell trans fusions were required. At 20 months post autograft, haematological complete remission persists.