Randomized controlled trial of the effect of early enteral nutrition on markers of the inflammatory response in predicted severe acute pancreatitis

Background: Recent evidence suggests that intestinal dysfunction has a role in sustaining the systemic inflammatory response in acute pancreatitis and may be ameliorated by the introduction of enteral nutrition. This study th erefore assessed the effect of early enteral nutrition on the systemic infl ammatory response in patients with prognostically severe acute pancreatitis . Methods: Patients with prognostically severe acute pancreatitis within 72 h of disease onset were randomized to receive either enteral nutrition or co nventional therapy consisting of a nil-by-mouth regimen. Serum interleukin (IL) 6, soluble tumour necrosis factor receptor I (sTNFRI) and C-reactive p rotein (CRP) were used as markers of the inflammatory response. Intestinal function was assessed using a differential sugar permeability technique. Results: Of 27 patients, 13 received enteral nutrition. A median of 21 (ran ge 0-100) per cent of calorific requirements was delivered over the first 4 days by enteral nutrition. There were no significant complications of ente ral nutrition. The introduction of enteral nutrition did not affect the ser um concentrations of IL-6 (P = 0.28), sTNFRT (P= 0.53) or CRP (P= 0.62) ove r the first 4 days of the study. Although there were no significant differe nces in intestinal permeability between the two patient groups at admission (chi(2)=2.33, d.f.=1, P=0.13), by day 4 abnormal intestinal permeability o ccurred more frequently in patients receiving enteral nutrition (chi(2) =4. 94, d.f.=1, P=0.03). Conclusion: Early enteral nutrition did not ameliorate the inflammatory res ponse in patients with prognostically severe acute pancreatitis. Furthermor e, it did not have a beneficial effect on intestinal permeability.