Purpose: To determine the success rate, safety and complications using a st
andard protocol and trained nurses to provide sedation for MRI under the su
pervision of a radiologist.
Materials and Methods: Nurses were trained to provide sedation via a standa
rd protocol for pediatric patients undergoing diagnostic MRI. Oral chloral
hydrate (80-100 mg.kg(-1))was used for children less than 18 mo of age. Old
er children received either 1-6 mg.kg(-1) pentobarbital iv, with or without
1-2 mu g.kg.hr(-1) fentanyl, or 25 mg.kg(-1) thiopental pr. Sedation was d
efined as successful if it allowed completion of the MRI without image dist
orting patient movement. The records of 572 MRIs performed on 488 pediatric
patients (mean age 5 +/- 4 yr; age 2 mo- 14 yr) from 1991 to July 1995 wer
e reviewed to determine the success rate and complications using the sedati
on program.
Results: Most, 91.8% (525/572), of the MRIs were successfully completed in
445 patients. The reasons for failure were inadequate sedation (45, 95.7%)
and coughing (2, 4.2%). The failure rate was much higher before 1994 (38/27
2, 14%) than after (9/300, 3%; P < 0.0001). Failure was more common if rect
al thiopental was used (23/172, 14%) than intravenous pentobarbital (19/256
, 7.4%; P < 0.05). The failure rate was also high in patients with a histor
y of a behavioural disorder (10/59, 17%). There were no deaths or unexpecte
d admissions as a result of the sedation program.
Conclusion: A high success rate can be achieved as experience is gained usi
ng a standard protocol and trained nurses to sedate children for MRI.