Total synthesis of the natural antigen involved in the hyperacute rejection response to xenotransplants

Authors
Gege, C Kinzy, W Schmidt, RR
Citation
C. Gege et al., Total synthesis of the natural antigen involved in the hyperacute rejection response to xenotransplants, CARBOHY RES, 328(4), 2000, pp. 459-466
Citations number
14
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215 → ACNP
Volume
328
Issue
4
Year of publication
2000
Pages
459 - 466
Database
ISI
SICI code
0008-6215(20001006)328:4<459:TSOTNA>2.0.ZU;2-N
Abstract
The major glycosphingolipid in pig vascular endothelium is the ceramide pen tasaccharide Gal alpha(1 --> 3)Gal beta(1 --> 4)GlcNAc beta(1 --> 3)Gal bet a(1 --> 4)Glc beta(1 --> 0)Cer (1), which binds specifically to human anti- Gal antibody and is involved in the hyperacute rejection response in xenotr ansplantation from pig to man. The synthesis of 1 and its methyl glycoside 2 is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.