Chinese-made electrolytic detachable coil in the embolization of a dog aneurysmal model

Objective To develop a Chinese-made electrolytic detachable coil (CEDC) tha t would allow patients to enjoy the benefit of electrolytic detachable coil without having to rely on the expensive Guglielmi detachable coil (GDC), a nd to test the safety and efficiency of CEDC. Methods Radiopacity of the marker of the CEDC was tested. The anti-strain f orce of coils and connection points were measured. In vitro and in vivo ele ctrolyses were conducted. We produced 21 aneurysm models including lateral, bifurcation, and terminal aneurysm models, and embolized 18 models with CE DC. Results Radiopacity of the marker was satisfactory. Anti-strain of the coil and the connection point have shown the safety and efficiency of CEDC. Ele ctrolysis in vitro and vivo, was similar to that of GDC. 83% of the aneurys m models were completely occluded. Coils were found to induce thrombosis in the aneurysm cavity, and could lead to a new endothelium over the entrance of the aneurysm, with organized tissue replacing thrombosis in 2 months. Conclusions CEDC is as efficient and safe as GDC. The marker, the ability t o induce thrombosis inside the sac and the growth of new endothelium over t he orifice are very satisfactory.