First human experience with pulmonary vein isolation using a through-the-balloon circumferential ultrasound ablation system for recurrent atrial fibrillation
A. Natale et al., First human experience with pulmonary vein isolation using a through-the-balloon circumferential ultrasound ablation system for recurrent atrial fibrillation, CIRCULATION, 102(16), 2000, pp. 1879-1882
Citations number
3
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background-Standard mapping and ablation of focal sources of atrial fibrill
ation are associated with very long procedure times and low efficacy. An an
atomic approach to complete pulmonary vein isolation could overcome these l
imitations.
Methods and Results-Fifteen patients with atrial fibrillation refractory to
medication underwent circumferential isolation of the pulmonary veins by u
sing a novel catheter, with an ultrasound transducer (8-MHz) mounted near t
he tip, in a saline-filled balloon. Twelve atrial foci and/or atrial fibril
lation triggers were identified in 9 patients (pulmonary vein locations: le
ft upper, 3; right upper, 6; right middle, 1; right lower, 1; and left infe
rior, 1). In 5 patients, lesions were placed in the absence of any mapped t
riggers. Irrespective of trigger mapping, circumferential isolation of both
upper pulmonary Veins was attempted in all patients. The lower pulmonary v
eins were ablated when sinus rhythm activation mapping revealed evidence of
a sleeve of atrial muscle in the vein. The median number of lesions per pa
tient required to isolate 1 pulmonary vein was 4 (range, 1 to 29). After ab
lation, no evidence of narrowing was seen with repeat Venography or follow-
up computed tomography scan. After a mean follow-up of 35 +/- 6 weeks, 5 pa
tients had recurrence of atrial fibrillation. Three responded to drugs that
were previously ineffective, and 2 remained in atrial fibrillation.
Conclusions-This novel ultrasound ablation system can successfully isolate
multiple pulmonary veins. At early follow-up, this approach seems to be eff
ective in preventing recurrent atrial fibrillation in a significant number
of patients.