Advances in three-dimensional reconstruction of the experimental spinal cord injury

Three-dimensional (3D) computer reconstruction is an ideal tool for evaluat ing the centralized pathology of mammalian spinal cord injury (SCI) where m ultiple anatomical features are embedded within each other. Here, we evalua te three different reconstruction algorithms to three-dimensionally visuali ze SCIs, We also show for the first time, that determination of the volume and surface area of pathological features is possible using the reconstruct ed 3D images themselves. We compare these measurements to those calculated by older morphometric approaches. Finally, we demonstrate dynamic navigatio n into a 3D spinal cord reconstruction (C) 2000 Elsevier Science Ltd. All r ights reserved.