This paper presents a new software, Pk-fit, to fit nonlinear models to kine
tic and dynamic data. Directly connected to the spreadsheet, a statistical
software component manager is available. In the data manager, Pk-fit includ
es the noncompartmental analysis module, the compartmental analysis module,
the nonlinear kinetic process module, the drug absorption module, the phar
macodynamic data modeling module, the simultaneous fitting module, and the
user-defined library module. In this paper, we present a detailed compariso
n of the kinetic analysis using Pk-fit and common software packages, PCNONL
IN, MODLIT, MKMODEL, NONMEM, and SIPHAR, based on the textbook published by
Gabrielsson in 1992, "Compilation of Analyzed Data Sets for Pharmacokineti
c Software Evaluation." The comparison of Pk-fit with the reference softwar
es revealed that the parameters and their dispersion found with Pk-fit are
consistent with the ones estimated with the other programs. In conclusion,
Pk-fit constituted a valid tool for pharmacokinetic/pharmacodynamic data an
alysis. (C) 2000 Academic Press.