Computational enzymology

Authors
Bruice, TC Kahn, K
Citation
Tc. Bruice et K. Kahn, Computational enzymology, CURR OP C B, 4(5), 2000, pp. 540-544
Citations number
65
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
4
Issue
5
Year of publication
2000
Pages
540 - 544
Database
ISI
SICI code
1367-5931(200010)4:5<540:CE>2.0.ZU;2-K
Abstract
Recent advances in computational methods and the availability of fast, affo rdable computers have made the modeling of enzymatic reactions practical. T he remaining challenges include achieving the accuracy level at which therm odynamic parameters and kinetic constants for different substrates, mutant enzymes, or in the presence of allosteric effecters can be predicted quanti tatively.