CCKB GASTRIN RECEPTOR ANTAGONISTS AS POTENTIAL-DRUGS FOR PEPTIC-ULCERTHERAPY/

Cholecystokinin (CCK) and gastrin are gastrointestinal polypeptide hor mones that exert several regulatory functions on motility and secretio n in the gastrointestinal tract. Their biological functions are mediat ed by different receptors located on the target tissues. Several selec tive and potent nonpeptide CCKB/gastrin receptor antagonists have been synthesized and are currently being studied. This review describes th e development of different classes oi these antagonists, and looks at future potential therapeutic benefits of such agents.