Camptothecin and mitomycin combination chemotherapy on ovarian clear cell carcinoma with multiple systemic metastases

Ovarian clear cell carcinoma is known for decreased responsiveness to most anticancer drugs, and the prognosis of patients with ovarian clear cell tum ors is very poor. We report such a patient with multiple systemic metastase s who showed a complete response to combined camptothecin and mitomycin che motherapy. During therapy, clinical drug-resistance was observed transientl y, but response was restored by intermittent administrations of camptotheci n. Such combination chemotherapy may be a useful alternative regimen for ad vanced and/or metastatic ovarian clear cell carcinoma.