Estimation of neovascularisation in hyperplasia and carcinoma of endometrium using a "power" angio-Doppler technique

The aim of this study was to estimate neovascularisation in hyperplasia and carcinoma of the endometrium using a "power" angio-Doppler technique. One hundred and eighty-two postmenopausal patients with irregular bleeding from the sexual organs were investigated. Age of the patients ranged betwee n 46 and 78 years. No neovascularisation in a control group of women with normal histopatholog ical results of the endometrium was observed. The sensitivity of this metho d with reference to the diagnosis of hyperplasia and cancer of the endometr ium was 12.2% and 81.2%, respectively. The specificity and positive predict ion values were equal to 100% each in both pathologies. The values of the a nalysed flow indices in the neovascular arteries in endometrial cancer were significantly lower (p<0.05) (properly PI-0.92+/-0.12; RI 0.46+/-0.08) in comparison to the corresponding values in hyperplasia of the endometrium (P I-1.38+/-0.28 and RI-0.66+/-0.18). In conclusion, using a "power" angio-Doppler technique irregular vascularit y of the endometrium in a group of patients with hyperplasia was observed i n 12.2% of all patients and in 81.2% of those with cancer of the endometriu m. The analysis of the values of the blood flow qualitative parameters in t he neovascularisation areas in the endometrium at the significance level of PI less than or equal to 1.0; RI less than or equal to 0.5 and TAMV>18.0 c m can help determine the essential element in the differential diagnosis of benign and malicious lesions. Transvaginal ultrasonography with a "power" angio-Doppler technique can be a valuable diagnostic method in hyperplasia and cancer of the endometrium, especially useful in the early stages of the se pathologies.