Inhibitory effect of apple pectin and culture condensate of bifidobacterium longum on colorectal tumors induced by 1,2-dimethylhydrazine in transgenic mice harboring human prototype c-Ha-ras genes

The number and tumor score of colorectal tumors induced by 1,2-dymethylhydr azine in transgenic (Tg) mice carrying human c-Ha-ras genes were significan tly reduced by ingestion of apple pectin (AP) or a culture condensate of Bi fidobacterium longum (MB) when compared with a control diet. There was no s tatistical difference in the incidence of colorectal tumors in Tg mice betw een the AP or MB diet and the control diet. This study demonstrated that Tg mice are a useful tool for screening inhibition of colorectal tumors by fu nctional foods.